Importance

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Abstract

The invention provides a circulating type biochemical reaction apparatus for carrying out hybridization efficiently and uniformly having a plate-like member 5 having a channel 6 for circulating a sample solution, a flow-in port 7, a flow-out port 8, flow-rectifying protrusions 9 formed thereon, and a plate-like member having a hollow 3 formed thereon for holding a probe substrate 1 to be combined and fixed together to form a unit. The unit is disposed with an inclination from a horizontal plane, with the flow-in port 7 coming at a lower level than the flow-out port 8. The sample solution is fed through the flow-in port 7 to be poured into the channel and circulated. The circulation improves the reaction efficiency and thereby increases signal intensities and reduces reaction time. Furthermore, the reaction proceeds uniformly such that the signal intensity is also.

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First Claim