Carboxyfullerenes and methods of use thereof
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United States of America Patent
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Issued Date -
Aug 28, 2003
app pub date -
Feb 23, 2002
filing date -
Feb 23, 2002
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The instant invention is a method for increasing a metazoan's lifespan, comprising administering a carboxylated derivative of a C.sub.60 fullerene. The instant invention further is a process for extending a metazoan's lifespan by administering a superoxide dismutase-mimetic as well as a composition comprising a superoxide dismutase-mimetic. Further, the instant invention comprises a pharmaceutical composition comprising carboxyfullerenes having x pairs of adjacent carbon atoms bonded to two carbons of the C.sub.60 sphere wherein said adjacent carbon atom is further bonded to two groups of the general formula --COOH and --R, wherein R is independently selected from the group consisting of --COOH and --H, and wherein x is at least 1. A further embodiment is a non-metal containing composition which can catalytically eliminate two biologically reactive species. Another embodiment is a method of enhancing elimination of reactive oxygen species in eukaryotic cells by contacting cells with a superoxide dismutase mimetic.
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