Protease and an aminopeptidase associated with development of benign prostatic hyperplasia (BPH)
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United States of America Patent
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Issued Date -
Sep 4, 2003
app pub date -
May 18, 2001
filing date -
May 18, 2001
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Abstract
Methods for identification and isolation of a benign prostate specific antigen (BPSA) protease and BPSA aminopeptidase are provided. The BPSA protease of the present invention preferentially cleaves prostate specific antigen (PSA) at residue Lys182 and does not react with the residue Arg85. The BPSA aminopeptidase cleaves BPSA between residues Ile1 and Val2 and between residues Lys146 and Leu147, but does not cleave BPSA at Ser183.
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