Methods for modulating an immune response by modulating the interaction between CTLA4 and PP2A
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United States of America Patent
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Issued Date -
Sep 4, 2003
app pub date -
Feb 15, 2002
filing date -
Feb 16, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention provides methods for modulating an immune response comprising contacting a cell with an agent that modulates the interaction between CTLA4 and PP2AA via modulating the lysine rich motif of CTLA4. The invention further provides methods for treating a subject having a disorder that would benefit from down regulation of an immune response comprising administering an agent that modulates the interaction between CTLA4 and PP2AA via modulating the lysine rich motif of CTLA4. The invention also provides methods for identifying compounds capable of modulating the interaction of CTLA4 and PP2AA.
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