Injectable depot compositions and uses thereof
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United States of America Patent
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N/A
Issued Date -
Sep 11, 2003
app pub date -
Nov 14, 2002
filing date -
Nov 14, 2001
priority date (Note) -
Abandoned
status (Latency Note)
Importance
Abstract
Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, an aromatic alcohol having miscibility in water of less than or equal to 7 wt. % at 25.degree. C., in an amount effective to plasticize the polymer and form a gel therewith, and a beneficial agent. The composition may additionally contain an ester of an aromatic acid, or an aromatic ketone. The compositions are readily implanted beneath a patient's body surface by injection, as the aromatic alcohol not only facilitates solubilization of the polymer, but also acts as a thixotropic agent, substantially increasing the shear thinning behavior of the composition.
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