Catheter injectable depot compositions and uses thereof
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United States of America Patent
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Nov 9, 2010
Grant Date -
Sep 25, 2003
app pub date -
Nov 14, 2002
filing date -
Nov 14, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Catheter injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.
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