Substituted 2-aminobenzamide caspase inhibitors and the use thereof
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United States of America Patent
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Issued Date -
Sep 25, 2003
app pub date -
May 9, 2003
filing date -
Mar 16, 1999
priority date (Note) -
Abandoned
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Abstract
The present invention is directed to novel 2-aminobenzamide thereof, represented by the general Formula I: 1 where R.sub.1-R.sub.3, X, and A-D are defined herein. The present invention also relates to the discovery that compounds having Formula I are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
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