RNA interference mediated treatment of Alzheimer's disease using short interfering RNA
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United States of America Patent
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Issued Date -
Oct 9, 2003
app pub date -
Jul 25, 2002
filing date -
Feb 20, 2002
priority date (Note) -
Abandoned
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Abstract
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications associated with Alzheimer's disease. Specifically, the invention relates to small interfering RNA (siRNA) molecules capable of mediating RNA interference (RNAi) against beta-secretase (BACE), PIN-1, presenillin-1 (PS-1) and presenillin-2 (PS-2) polypeptide and polynucleotide targets.
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