Importance

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Abstract

A capsule, or a matrix, of a substance, most typically a polymer, that is degraded by a photo-acid or, less preferably, by a photo-base, physically contains or incorporates (i) a photo-acid, or a photo-base, or precursors to same, and (ii) one or more molecular agents, normally drugs. Placed in vivo, the photo-acid or photo-base or its precursors is (are) changed into an acid or base, as the case may be, by impinging radiation, most preferably by one or more light beams of green or longer wavelengths to which tissues are transparent, or else x-rays. The preferred light beams are two in number, spatially and temporally intersecting to produce the acid or base in vivo at precise regions and times by process of two-photon absorption. The photogenerated acid or base ruptures or dissolves the containment capsules or matrix, loosing the contained molecular agents (i) at precise subcutaneous tissue locations (ii) at precise rates (iii) over precise time intervals.

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First Claim