Method for determining analyte concentration using periodic temperature modulation and phase detection
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United States of America Patent
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Feb 28, 2006
Grant Date -
Oct 23, 2003
app pub date -
Apr 28, 2003
filing date -
Mar 12, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. Reference and analytical signals are detected. In the presence of the selected analyte, parameter differences between reference and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample. Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical and reference signals may be measured continuously and the parameter difference integrated over the measurement period to determine analyte concentration.
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