Modified biological peptides with increased potency
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United States of America Patent
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Issued Date -
Oct 30, 2003
app pub date -
Mar 3, 2003
filing date -
Aug 2, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention is concerned with modified biological peptides providing increased potency, prolonged activity and/or increased half-life thereof. The modification is made via coupling through an amide bond with at least one conformationally rigid substituent, either at the N-terminal of the peptide, the C-terminal of the peptide, on a free amino or carboxyl group along the peptide chain, or at a plurality of these sites. Those peptides exhibit clinical usefulness for example in treating states of insulin resistance associated with pathologies such as type II diabetes.
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