Expression system for effeiciently producing clinically effective lysosomal enzymes (glucocerebrosidase)
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United States of America Patent
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Issued Date -
Nov 20, 2003
app pub date -
May 6, 2003
filing date -
Apr 6, 2000
priority date (Note) -
Abandoned
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Abstract
The invention as described herein relates to the efficient production of recombinant, clinically effective lysosomal enzymes using a transformed insect cell expression system. For example, to create the expression system of the invention, any insect cell can be transfected with a plasmid comprised of a gene encoding the human glucocerebrosidase gene and genetic elements that enhance its expression. The insect cell transfected with the plasmid encoding glucocerebrosidase secretes synthesized glucocere-brosidase into its growth media. The recombinantly produced clinically effective glucocerebrosidase produced by the insect cell expression system can be used to treat Gaucher's disease.
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