Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation
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United States of America Patent
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Issued Date -
Dec 11, 2003
app pub date -
Mar 12, 2003
filing date -
Apr 13, 1998
priority date (Note) -
Abandoned
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Abstract
Iterative, preferably computer based iterative processes for generating synthetic compounds capable of modulation of target expression are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A 'virtual' oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Compounds exhibiting the ability to modulate target expression are identified as target modulators. Target modulators thus generated are used in assays of parameters indicative of biological processes to effect gene function analysis and in assays of parameters indicative of diseases or disorders to effect target valid
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