Methods and apparatus for enhancing a response to nucleic acid vaccines
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United States of America Patent
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Jun 26, 2002
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Jun 26, 2002
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Abstract
The immune response achieved by the administration of nucleic acid vaccines is enhanced by the application of vibrational energy to the inoculated tissue region. The vibrational energy is selected to enhance transfection of the tissue without substantial tissue damage, relying on a mechanical effect of the vibrational energy. Additionally, vibrational energy intended to mechanically injure the tissue via a thermal effect may also be applied.
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