Specific inhibitors of NFAT activation by calcineurin and their use in treating immune-related diseases

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United States of America Patent

APP PUB NO 20040002117A1
SERIAL NO

10358052

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Abstract

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Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein-protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions and methods for high throughput screening of candidate agents are described. Pharmaceutical compositions are also provided.

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Patent Owner(s)

Patent OwnerAddress
CBR INSTITUTE OF BIOMEDICAL RESEARCH INC THE800 HUNTINGTON AVENUE BOSTON MA 02115

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aramburu, Jose Barcelona, ES 4 22
Hogan, Patrick G Cambridge, MA 8 56
Kang, Sunghyun Brookline, MA 3 11
Rao, Anjana Cambridge, MA 75 871
Roehrl, Michael H A Brookline, MA 1 5
Wagner, Gerhard Chestnut Hill, MA 72 330

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