Lysosomal proteins produced in the milk of transgenic animals
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United States of America Patent
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Issued Date -
Jan 1, 2004
app pub date -
Jan 23, 2003
filing date -
Aug 2, 1995
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6' position of a mannose side chain residue. Also provided are methods of purifying lysosomal proteins from milk, and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy.
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