Treating dominant disorders

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20040009899A1
SERIAL NO

10195722

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention provides methods and materials for reducing the level of an RNA or polypeptide expressed by a mutant allele of a gene that causes a dominant disorder in a mammal. The methods include administering a PNA oligomer to a mammal that is heterozygous for such a mutant allele. By using these methods, the level of an RNA or polypeptide encoded by the mutant allele is reduced to a greater extent than the level of an RNA or polypeptide encoded by the non-mutant allele.

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Patent Owner(s)

Patent OwnerAddress
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH200 FIRST STREET SW ROCHESTER MN 55905

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
McMahon, Beth M Alameda, CA 1 0
McMurray, Cynthia T Oronoco, MN 2 0
Richelson, Elliott Ponte Vedra Beach, FL 40 89

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