Compositions and methods for the treatment of matrix metalloproteinase-related diseases
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United States of America Patent
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Issued Date -
Jan 15, 2004
app pub date -
Mar 18, 2003
filing date -
Mar 27, 2002
priority date (Note) -
Abandoned
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Abstract
The present invention relates to the use of water-soluble photo-stable silver thiosulfate ion complexes that are antimicrobially active and inhibit the activity of metalloproteinases. The present invention describes incorporation of these complexes into medical devices and/or wound dressings to prevent or treat symptomology related to microbial infections and/or conditions of excessive tissue destruction. In particular, these complexes may be useful in the treatment of rheumatoid arthritis and/or osteoarthritis in the prevention and treatment of articular bone joint degradation and subsequent reductions in joint swelling and pain.
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