Benzodiazepine inhibitors of mitochondial F1F0 ATP hydrolase and methods of inhibiting F1F0 ATP hydrolase
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United States of America Patent
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Issued Date -
Jan 15, 2004
app pub date -
Jun 13, 2003
filing date -
Jun 17, 2002
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Compounds having the formula (I), 1 are useful as inhibitors of mitochondrial F.sub.1F.sub.0 ATP hydrolase, wherein R.sub.1, R.sub.5 and R.sub.7 are optional substituents, R.sub.2, R.sub.3 and R.sub.4 are hydrogen, alkyl, or substituted alkyl, or comprise a bond to R, T or Y; Z and Y are selected from C(.dbd.O), --CO.sub.2--, --SO.sub.2--, --CH.sub.2--, --CH.sub.2C(.dbd.O)--, and --C(.dbd.O)C(.dbd.O)--, or Z may be absent; R and T are CH.sub.2--, --C(.dbd.O)--, or --CH[(CH.sub.2).sub.p(Q)]--, wherein Q is NR.sub.10R.sub.11, OR.sub.10 or CN and p is 0, 1 or 2; R.sub.6 is alkyl, alkenyl, substituted alkyl, substituted alkenyl, aryl, cycloalkyl, heterocyclo, or heteroaryl; R.sub.10 and R.sub.11 are hydrogen, alkyl, or substituted alkyl; and r and t are 0 or 1.
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