Derivatives of soluble T-4

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United States of America Patent

SERIAL NO

09891119

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +185 fused to the amino acid sequence from about +353 to about +371. In another embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +106 fused to the amino acid sequence from about +353 to about +371. In yet a further embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +185. This invention also provides a method for treating a subject infected with a human immunodeficiency virus. The method comprises administering to the subject an effective amount of a pharmaceutical composition comprising an effective amount of a therapeutic agent of the invention and a pharmaceutically acceptable carrier.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF COLUMBIA UNIVERSITYNEW YORK NY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arthos, James Ann Arbor, MI 9 56
Axel, Richard New York, NY 30 2002
Maddon, Paul J New York, NY 89 993
Sweet, Raymond W Bala Cynwyd, PA 23 573

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