Controlled drug delivery system using the conjugation of drug to biodegradable polyester
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United States of America Patent
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Jan 16, 2007
Grant Date -
Jan 22, 2004
app pub date -
Apr 25, 2003
filing date -
May 16, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to the molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect. Moreover, the high loading efficiency of hydrophilic drugs can be achieved.
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