Oligonucleotide analogues and methods of use for modulating gene expression
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United States of America Patent
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Issued Date -
Jan 22, 2004
app pub date -
Feb 7, 2003
filing date -
Mar 14, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention relates generally to oligonucleotide analogues that include novel protein nucleic acid molecules (PNAs), particularly monomers, dimers, oligomers thereof and methods of making and using these oligonucleotide analogues. The PNAs of the present invention are characterized as including a variety of classes of molecules, such as, for example, hydroxyproline peptide nucleic acids (HypNA), and serine peptide nucleic acids (SerNA). The present invention also includes the use of oligonucleotides of the present invention in antisense and homologous recombination constructs and methods.
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