Injectable multimodal polymer depot compositions and uses thereof
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United States of America Patent
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Aug 6, 2013
Grant Date -
Feb 5, 2004
app pub date -
Jul 28, 2003
filing date -
Jul 31, 2002
priority date (Note) -
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Abstract
Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein each polymer of the plurality of polymers has a specified average molecular weight, and the polymer matrix has a broad molecular weight distribution of the plurality of polymers; a solvent having a miscibility in water of less than or equal to 7 wt % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith; and a beneficial agent. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.
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