Antagonistic peptides of prostaglandin E2 receptor subtype EP4
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United States of America Patent
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Issued Date -
Feb 5, 2004
app pub date -
May 23, 2003
filing date -
May 23, 2002
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Abandoned
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Abstract
Antagonistic peptides of prostaglandin E2 receptor subtype EP4 and their use in the treatment or prevention of medical conditions associated with oligouric nephropathy, bone resorption, abnormal intestinal crypt cell proliferation or patency of the ductus arteriosus and the like are provided herein. The antagonistic peptides of the present invention possess the following general formula: 1 wherein X is selected from the group consisting of a hydrogen atom, a sequence of 1 to 3 amino acids, and protecting groups such as a carbamate group and an acyl group; and wherein Y is selected from the group consisting of a hydrogen atom, 1 to 5 L-lysine residues, phosphate, sulfate and 1 to 5 ethylene glycol residues.
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