Identification of essential genes in microorganisms
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United States of America Patent
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Issued Date -
Feb 12, 2004
app pub date -
Oct 25, 2002
filing date -
Oct 25, 2001
priority date (Note) -
Abandoned
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Abstract
The sequences of antisense nucleic acids which inhibit the proliferation of prokaryotes are disclosed. Cell-based assays which employ the antisense nucleic acids to identify and develop antibiotics are also disclosed. The antisense nucleic acids can also be used to identify proteins required for proliferation, express these proteins or portions thereof, obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous nucleic acids that are required for proliferation in cells other than Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms.
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- 15 United States
- 10 France
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Patent Owner(s)
Patent Owner | Address | |
---|---|---|
MERCK & CO INC | P O BOX 2000 RY60-30 RAHWAY NJ 07065-0907 |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Carr, Grant J | Escondido, CA | 6 | 403 |
Forsyth, R Allyn | San Diego, CA | 8 | 383 |
Haselbeck, Robert | San Diego, CA | 21 | 610 |
Malone, Cheryl | Santee, CA | 2 | 277 |
Ohlsen, kari L | San Diego, CA | 6 | 412 |
Trawick, John D | La Mesa, CA | 35 | 887 |
Wall, Daniel | San Diego, CA | 11 | 415 |
Wang, Liangsu | San Diego, CA | 4 | 280 |
Xu, H Howard | San Diego, CA | 4 | 401 |
Yamamoto, Robert | San Diego, CA | 1 | 273 |
Zamudio, Carlos | La Jolla, CA | 38 | 971 |
Zyskind, Judith W | La Jolla, CA | 9 | 496 |
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Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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