Gene cluster for thienamycin biosynthesis, genetic manipulation and utility
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United States of America Patent
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Issued Date -
Feb 26, 2004
app pub date -
Feb 26, 2003
filing date -
Apr 4, 2002
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Abandoned
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Abstract
Isolation, cloning and sequencing of the cluster of genes involved in the biosynthesis of the carbapenem thienamycin by streptomyces cattleya, and the use of those genes to increase thienamycin production, and/or related antibiotics, in the producing strains, and obtaining new derivatives by means of genetic manipulation which implies gene expression, mutagenesis by gene replacement and combinatorial biosynthesis.
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