Compositions and methods for detecting nucleic acid methylation
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United States of America Patent
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Issued Date -
Feb 26, 2004
app pub date -
Mar 10, 2003
filing date -
Mar 8, 2002
priority date (Note) -
Abandoned
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Abstract
Methods and compositions are provided for detecting the presence or absence of methylation at methylation sites in a target nucleic acid sequence, utilizing probe sets complementary to first and second binding domains located upstream and downstream of one or more methylation sites of interest in a nucleic acid sequence. Methylation determination may be combined with the detection of additional polymorphisms, such as single nucleotide polymorphisms and/or gene dosage determinations, to provide a more complete genetic profile at a locus or loci of interest.
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