Phthalazine derivatives as phosphodiesterase 4-inhibitors
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United States of America Patent
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app pub date -
May 20, 2003
filing date -
Dec 19, 1997
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Abstract
A process for preparing a compound of formula I: 1 wherein G is methylene, ethylene, CONH, amino or a bond; R is H, phenyl or a (C.sub.1-4)alkyl group optionally substituted by phenyl; Cy is phenyl or a 5- or 6-membered heterocycle of the group consisting of pyrrole, imidazole, pyrazole, pyrrolidine, pyrroline, imidazoline, imidazolidine, pyrazolidine, pyrazoline, pyridine, pyrazine, pyrimidine, pyridazine, piperazine, piperidine, and triazine, the Cy residue being optionally substituted by one or more substituent(s) selected from the group consisting of keto, nitro, carboxy, fluorine, chlorine, bromine, or iodine; R.sub.1 is a (C.sub.1-6)alkyl or polyfluoro(C.sub.1-6)alkyl group; and R.sub.2 is aryl, aryl-(C.sub.1-10)-alkyl, (C.sub.4-7)cycloalkyl or (C.sub.4-7)heterocycle wherein the heteroatom is an oxygen atom.
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