Compositions of tocol-soluble therapeutics
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United States of America Patent
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Issued Date -
Mar 18, 2004
app pub date -
Jan 25, 2002
filing date -
Sep 27, 1999
priority date (Note) -
Abandoned
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Abstract
Tocol-based compositions of charged amphiphilic and water soluble pharmaceutically active compounds or their charged precursors are prepared by forming a tocol-soluble ion pair with an oppositely charged ion-pair forming compound capable of forming a tocol-soluble ion-pair with the active compound. Also disclosed are novel compounds tocopherolsuccinate-aspartate and tocopherolsuccinate-glutamate, which are useful as ion-pair forming compounds.
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