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Abstract

This invention relates to reagents and methods for synthesis of biologically active di- and tri-saccharides comprising .alpha.-D-Gal(1.fwdarw.3)-D-Gal. In particular the invention provides novel reagents, intermediates and processes for the solution or solid phase synthesis of .alpha.-D-galactopyranosyl-(1.fwdarw.3)-D-galactose, and derivatives thereof. In one preferred embodiments the invention provides a protected monosaccharide building block of general formula (II): in which R.sup.3 is methoxy or methyl; R.sup.1 is H, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl; and R.sup.2 is H, Fmoc, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl. 1

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First Claim