Process for the preparation of L-amino acids using a gene encoding 6-phosphogluconate dehydrogenase
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United States of America Patent
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app pub date -
Oct 17, 2003
filing date -
Mar 20, 2000
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Abstract
The invention relates to a process for the preparation of L-amino acids. The process involves fermenting an L-amino acid producing coryneform bacteria in a culture medium, concentrating L-amino acid produced by the fermenting in the culture medium or in the cells of the bacteria, and isolating the L-amino acid produced. The bacteria has an overexpressed gene encoding 6-phosphogluconate dehydrogenase and a decreased or switched off gene encoding pyruvate oxidase. The L-amino acid may be L-lysine, L-threonine, L-isoleucine or L-tryptophan. `
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