Process for the manufacture of pharmaceutical tablets contaning paroxetine hydrochloride anhydrate
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United States of America Patent
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Issued Date -
Apr 15, 2004
app pub date -
Aug 26, 2003
filing date -
Mar 2, 2001
priority date (Note) -
Abandoned
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Abstract
Pharmaceutical tablets containing crystalline paroxetine hydrochloride anhydrate are prepared using a process comprising an initial wet granulation process in which an aqueous granulation liquid is added to a mixture of said anhydrate an excipients under high-shear conditions and the thus obtained wet granules are dried using a fluidized bed technique to obtain a water activity within a specified range, after which the dried granules after addition of further adjuvants are compressed into stable tablets each having an identical composition.
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