P-glycoproteins and uses therefor
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United States of America Patent
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Issued Date -
Apr 22, 2004
app pub date -
Jul 14, 2003
filing date -
Sep 28, 1999
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The invention pertains to cynomologous monkey P-glycoproteins and related P-glycoproteins which include cynomologous-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the cynomologous monkey P-glycoprotein. The invention further relates to methods of using such cynomologous monkey P-glycoprotein nucleic acids and polypeptides, especially in methods for determining bioavailability of drugs and for screening for inhibitors of cynomologous PGP. Also included are cynomologous PGP inhibitors which inhibit cynomologous PGP activity by inhibiting the expression or function of cynomologous PGP.
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