Sustained release composition for oral administration of drugs
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United States of America Patent
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Apr 27, 2010
Grant Date -
Apr 29, 2004
app pub date -
Aug 27, 2003
filing date -
Oct 23, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A sustained-release composition for oral administration of a drug, comprising the drug, a mixture of sodium alginate and xanthan gum as a carrier for sustained release and a mixture of hydroxypropyl methylcellulose and propylene glycol alginate as a gel hydration accelerator, which is capable of maintaining a constant drug level in blood for 24 hours or more. Due to rapid gel hydration without forming a non-gelated core, the drug release rate follows zero order kinetics and does not significantly vary with the degree of gastrointestinal motility.
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