Enzyme-mediated modification of fibrin for tissue engineering
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
N/A
Issued Date -
Apr 29, 2004
app pub date -
Aug 27, 2003
filing date -
Apr 3, 1997
priority date (Note) -
Abandoned
status (Latency Note)
Importance
Abstract
Matrices covalently bound to bidomain peptides or proteins, produced recombinantly or synthetically, contain a transglutaminase substrate domain and a bioactive factor. The bioactive factor is preferably a growth factor, such as VEGF, growth factors from the TGF-.beta. superfamily, PDGF, human growth hormone, IGF, and ephrin. Particularly preferred growth factors are TGF-.beta.1, BMP 2; VEGF.sub.121 and PDGF AB. The matrix material is crosslinkable, and may form a gel. These compositions are useful for tissue repair and regeneration.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully