Casein peptide fragments with growth-influencing activity on cell cultures

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United States of America Patent

APP PUB NO 20040086965A1
SERIAL NO

10380371

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Abstract

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From an enzymatic hydrolysate of bovine casein there was isolated a decapeptide whose sequence could be clearly identified in the primary sequence of the casein. This decapeptide, which was also prepared by synthetic chemistry, influences the growth of the insect cell line IPLB-Sf-21 in a concentration-dependent manner. A tripeptide, which is present twice in the sequence of the decapeptide and the casein, has an even more pronounced action than the decapeptide, that action likewise being concentration-dependent. These peptides can accordingly be used advantageously as additives for serum-free, chemically defined cell culture media.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSIDAD NACIONAL DEL LITORALPASAJE MARTINEZ 2626 SANTA FE - PCIA DE SANTA FE 3000
GESELLSCHAFT FUER BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF)MASCHERODER WEG 1 D-38124 BRAUNSCHWEIG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Claus, Juan Sante Fe, AR 1 0
Comini, Marcelo Santa Fe, AR 1 0
Frank, Ronald Braunschweig, DE 31 520
Perin, Juan Carlos Santa Fe, AR 1 0
Salvetti, Jorge Luis Santa Fe, AR 1 0
Tonarelli, Georgina Santa Fe, AR 1 0

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