Therapeutically useful compositions of DNA-RNA hybrid duplex constructs
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United States of America Patent
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Issued Date -
May 6, 2004
app pub date -
Mar 19, 2003
filing date -
Nov 12, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention provides novel compositions and methods for suppressing the expression of a targeted gene using RNA-DNA hybrid constructs. The invention further provides novel methods and compositions for generating or producing RNA-DNA hybrids, whose quantity is high enough to be used for the invention's gene silencing transfection and possibly in therapeutics applications. This improved RNA-polymerase chain reaction method utilizes thermocycling steps of promoter-linked DNA or RNA template synthesis, in vitro transcription and then reverse transcription to bring up the amount of RNA-DNA hybrids up to two thousand folds within one round of the above procedure for specific gene silencing.
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