Compositions and methods of treating neurological disease and providing neuroprotection
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United States of America Patent
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Issued Date -
May 27, 2004
app pub date -
May 22, 2003
filing date -
May 22, 2002
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Pharmaceutical compositions and methods of use thereof for the acute, chronic and prophylactic treatment of neurologic and neurodegenerative diseases, attenuation of acute or chronic neuronal damage in neurological disease ('neuroprotection'), and prophylaxis of neurological diseases, where the neurological diseases may involve excessive stimulation of the NMDA receptor, hypofunction of the NMDA receptor, up- or down regulation of the NMDA receptor, and abnormal subunit structure or function of the NMDA receptor. The pharmaceutical compositions are open-channel antagonists of the NMDA (N-methyl-D-aspartate) receptor complex, and include memantine (a 1-amino-3,5-dimethyl-adamantane hydrochloride), felbamate, acamprosate, and MRZ 2/579. The invention relates to oral, controlled or sustained release, intravenous, rectal, transcutaneous or other preparations such as lipid emulsion or crystal technology.
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