Method of inhibiting opioid tolerance with chimeric hybrid analgesics
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United States of America Patent
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Issued Date -
Jun 3, 2004
app pub date -
Oct 17, 2003
filing date -
Apr 26, 2002
priority date (Note) -
Abandoned
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Abstract
The present invention provides a method of inhibiting the development of opioid tolerance using novel chimeric hybrid molecules containing an opioid moiety of chemically modified morphine (3) that binds to and activates the human mu (.mu.) opioid receptor, with the opioid moiety linked through a novel linker-hinge (4) to a substance P peptide fragment moiety (5) that binds to and activates the human substance P receptor. The hybrid alkaloid/peptide analgesics may be administered intrathecally, systemically or orally.
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