Gene targeting in animal cells using isogenic DNA constructs

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20040107452A1
SERIAL NO

10722661

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides novel methods for modifying the genome of an animal cell which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications are contained in a segment of DNA (a 'targeting DNA') that is substantially isogenic with a DNA in the cell genome (a 'target DNA'); introducing the targeting DNA construct into the cell (e.g., by microinjection, electroporation, transfection, or calcium phosphate precipitation); and selecting cells in which the desired sequence modifications have been introduced into the genome via homologous recombination.

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Patent Owner(s)

Patent OwnerAddress
GENPHARM INTERNATIONAL INC521 COTTONWOOD DRIVE MILPITAS CA 95035

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berns, Anton Spaarndam, NL 6 867
Riele, Hein Te Amsterdam, NL 1 20
Robanus, Maandag Els Haarlem, NL 3 434

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