Sustained release dosage forms of anesthetics for pain management
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United States of America Patent
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N/A
Issued Date -
Jun 10, 2004
app pub date -
Oct 31, 2003
filing date -
Jun 25, 2002
priority date (Note) -
Abandoned
status (Latency Note)
Importance
Abstract
Drug delivery systems and kits are provided that release an anesthetic, such as bupivacaine, over a short duration. Methods of administering and preparing such systems are also provided. Drug delivery systems include a short duration gel vehicle and an anesthetic dissolved or dispersed in the gel vehicle. The gel vehicle comprises a low molecular weight bioerodible, biocompatible polymer and a water-immiscible solvent in an amount effective to plasticize the polymer and form a gel with the polymer. In some instances, a component solvent is used along with the water-immiscible solvent. An efficacy ratio, which is one way to measure the efficacy of a delivery system, can be controlled based on, for example, the construction of the gel vehicle to achieve a desired release profile.
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Family
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