Targeting endothelium for tissue-specific delivery of agents

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United States of America Patent

APP PUB NO 20040115128A1
SERIAL NO

10631481

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Mechanisms and routes by which molecules can be delivered into cells, particularly endothelial cells, through the action of caveolae, G domains and other plasma membrane domains and components, are described, as are delivery systems comprising antibodies to caveolar proteins or receptors and also agents conjugated to the antibody or ligand, which can be used to deliver agents to, into, and/or across the endothelium, for example, for imaging purposes.

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Patent Owner(s)

Patent OwnerAddress
BETH ISRAEL DEACONESS MEDICAL CENTER INC330 BROOKLINE AVENUE BOSTON MA 02215
SIDNEY KIMMEL CANCER CENTERSUITE 200 3099 SCIENCE PARK ROAD SAN DIEGO CA 92121 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Schnitzer, Jan E Encinitas, CA 17 148

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