Zis-sr nucleic acid and amino acid sequences involved in the regulated secretory pathway and/or the regulation of the neuroendocrine phenotype (nep)
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United States of America Patent
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Issued Date -
Jun 17, 2004
app pub date -
Feb 16, 2004
filing date -
Jan 29, 2002
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Abandoned
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Abstract
The present invention relates to genes and protein encoded thereby that regulate the secretory pathway and/or the neuroendocrine phenotype (NEP) in cells and method of isolating same. More particularly, the present invention relates to long-term therapies for diseases or conditions associated with a loss function. More particularly, the present invention relates to the treatment of such diseases using a cell replacement therapy. In particular, the invention relates to genes involved in cellular differentiation and genes that modulate the formation of the regulated secretory pathway. The invention thus also concerns a method to identify such genes, the genes, variants or fragments thereof, vectors comprising same, the products of these genes, variants or fragments thereof and to cells expressing same. In a particular embodiment, the invention relates to the characterization of Zis-SR a novel sequence involved in the secretory pathway in cells.
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