Sequestering subunit and related compositions and methods
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United States of America Patent
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Oct 19, 2010
Grant Date -
Jul 8, 2004
app pub date -
Sep 22, 2003
filing date -
Sep 20, 2002
priority date (Note) -
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Abstract
A sequestering subunit comprising an aversive agent and a blocking agent, wherein the blocking agent substantially prevents release of the aversive agent from the sequestering subunit in the gastrointestinal tract for a time period that is greater than 24 hours; a composition comprising a sequestering subunit and a therapeutic agent in releasable form, wherein, optionally, the mechanical fragility of the sequestering subunit is the same as the mechanical fragility of the therapeutic agent in releasable form; a capsule or tablet comprising a sequestering subunit and a therapeutic agent; and a method of preventing abuse of a therapeutic agent.
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