Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
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United States of America Patent
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Issued Date -
Jul 8, 2004
app pub date -
Sep 26, 2003
filing date -
Sep 26, 2002
priority date (Note) -
Abandoned
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Abstract
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable salts thereof, wherein R.sub.1 is a C.sub.2-C.sub.20 substituted or unsubstituted carboxyacyl, R.sub.2 is hydrogen, chloro, bromo, or hydroxy, R.sub.4 is hydrogen or C(C.sub.6H.sub.5).sub.3; wherein the dashed line represents an optional double bond between C20 and C29.
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