Expression of exogenous polynucleotide sequences in a vertebrate
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United States of America Patent
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Issued Date -
Jul 8, 2004
app pub date -
Dec 11, 2003
filing date -
Mar 21, 1989
priority date (Note) -
Abandoned
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Abstract
A method for delivering a naked or isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of a naked polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
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