Pharmaceutical formulations and methods for modified release of statin drugs
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United States of America Patent
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Issued Date -
Jul 8, 2004
app pub date -
Sep 3, 2003
filing date -
Sep 3, 2002
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention is directed to compositions and methods of their use in treating, preventing, and/or managing one or more cardiovascular diseases using at least one poorly water-soluble statin, such as, for example, simvastatin and/or lovastatin. One method of the invention involves delaying release of the poorly water-soluble statin for a time sufficient to avoid metabolism of the statin at or near the gastrointestinal tract wall by the cytochrome P450 3A metabolic system, and releasing said statin in the ileum, colon, or both, with subsequent uptake into the hepatic portal vein and distribution to hepatocytes, wherein HMG-CoA reductase activity may be inhibited with minimal adverse drug interactions.
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