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Abstract

A system and method for imaging tissue samples is provided having a confocal microscope integrated with the confocal microscope. Such tissue samples may represent excised tissue from Moh's micrographic surgery. The system enables a user, such as a Moh's surgeon, to examine the low-resolution image of the tissue sample provided by the macroscope and identity sites that potentially appear to be abnormal, and then further examine the nuclear morphology of tissue at such sites in high-resolution images from the confocal microscope to detect the presence of abnormal tissue structures (cells), such as cancer. One or more agents such as acetic acid and calcein AM may be applied to the tissue sample to enhance the contrast of tissue structures in confocal and/or macroscopic images. Optics may be provided to enable the system to operate the macroscopic and confocal microscope in reflectance or fluorescence imaging modes.

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First Claim