Overcoming DAPA aminotransferase bottlenecks in biotin vitamers biosynthesis
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United States of America Patent
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Issued Date -
Jul 29, 2004
app pub date -
Jan 9, 2004
filing date -
Jul 14, 1997
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Abandoned
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Abstract
A method is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. The method involves the use of a bacterium that is either grown in the presence of lysine or deregulated for lysine biosynthesis.
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