Use of enzyme inhibitors of the dipeptidypeptidase iv (ec3.3.14.5) in addition to the aminopeptidase n (ec 3.4.11.2), individually or in a combination thereof, and pharmaceutical preparations thereof for the prevention and/or therapy of ischaemia-caused acute and chronic neurodegenerative process and illnesses, for example
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United States of America Patent
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Issued Date -
Jul 29, 2004
app pub date -
Feb 12, 2004
filing date -
Jan 2, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention relates to a process wherein, by a separate or simultaneous administration and effect of inhibitors of the enzymes alanyl aminopeptidase (APN) and dipeptidyl peptidase IV (DP IV) or of enzymes having the same or a similar substrate specifity, the damage of cerebral tissue as a consequence of an ischemia or a cranial/cerebral trauma can be reduced or prevented. The invention shows that the separate or combined application of inhibitory substances of the above-mentioned enzymes or of corresponding preparations or administration forms is definitely suitable for a prevention and therapy of the above indications.
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